新一代表觀遺傳藥物研發全球領導者

- Epigenetics and Beyond

生物醫藥研發主管(上海)

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*需生物學背景

生物醫藥研發主管
JD of Biology Research Project Leader
職位信息:Position Information
職位名稱/Position Name: 生物學研發主管/ Biology Research Project Leader
月薪:行業標準,可面議
工作地點:上海張江(可選深圳)
入職時間:2021年8-9月
工作性質:全職
工作經驗:2年以上醫藥行業工作經驗(或工業界博后經驗)
最低學歷:博士
招聘人數:2人
職位類別:臨床前生物學藥理研究及轉化項目組領導

工作職責:
1.根據項目需求與項目團隊合作,制定和負責臨床前腫瘤新藥研發項目的工作目標,研發策略,體外、體內及疾病模型等具體的生物學研發工作,指導和協調內外部研發資源進行各項生物學研發實驗,把控項目研發中各環節的進程和質量,確保研究數據的真實性、完整性和可靠性。
2.根據研發項目腫瘤和其他疾病模型需求,建立各類體外、體內分子生物學、細胞生物學和動物實驗技術與模型,評估臨床前候選化合物的在動物模型上的藥效和藥理機制,發現和擴展候選藥物在更多適應癥的應用與生物標記物研究。
3.結合公司研發大方向以及與國內外學術機構的合作,啟動新研發立項和靶點驗證、方法和模型開發、化合物篩選與評價等工作
4. 對研究助理的實驗技術和數據分析進行指導,對結果進行分析總結,并向管理團隊匯報,負責與CRO,外部合作方等溝通,并監督和指導實驗進展。
5. 建立和協調與國內外學術研究機構良好的合作研究,參與論文撰寫和課題 申報工作,為公司其他項目的生物學技術提供支持,跟蹤國際生物技術領域最新趨勢和技術平臺,參與IND申報有關藥理/毒理和臨床轉化研究,
6. 參與公司管理的有關事務和其他業務,參與公司技術人員招聘和培訓,參與外部相關方的溝通交流

Key Responsibilities:
1. As a biology project team leader, work with the team to set goal and strategy, execute, guide and supervise internal/external research associates to carry out studies.
2. Develop phenotypical/functional assays for discovery of cancer drug candidates to better recapitulate the physiological or pathological condition. Lead internal/external pharmacology team to evaluate drug candidates for efficacy, drug-like properties and toxicity in relevant animal models. Explore and expand current drug candidates into broad indications for translational and biomarker studies.
3. Initiate with new target validation/exploration, in collaboration with domestic/oversea research groups. Interact with screening team for assay optimization, miniaturization and automation
4. Supervise the internal research assistants and external CRO groups for experimental detail, data analysis, interpretation,trouble-shooting and report writing. Present work progress to management and project team.
5. Establish good collaboration and communicate with external research groups from academy. Provide technical support for new project nominations and close external research collaborations. Track new platforms and technologies in drug discovery and keep up-to-date with the industry's latest developments. Involve in IND-enabling process (e.g., DMPK/GLP-tox) and clinical translational studies, etc.
6. Responsible for building, training, and managing the team. Participate in the company management including operation and recruiting.

應聘要求:
1. 分子生物學、生物化學、細胞生物學、腫瘤生物學、免疫學或其他相關生物/醫學專業博士學歷
2. 2年以上醫藥行業工作經驗(或工業界博后經驗)
3. 有腫瘤動物模型研究和/或腫瘤體內藥理/藥效研究經驗,熟系各類基因敲除/敲入/轉基因小鼠模型或CDX/PDX/PDC模型,對腫瘤體內模型樣品的biomarker/PD marker分析等。
4. 精通腫瘤生物學、免疫學、生物化學和分子生物學實驗技術,包括分子克隆、細胞培養、腫瘤細胞增殖/轉移/周期/功能實驗、細胞轉染、穩定細胞株構建、ELISA、 western-blot、RT-qPCR或者流式細胞技術富有經驗。
5. 具有獨立設計、執行、解讀實驗和數據的經驗能力,具有管理單個甚至多個研發項目的能力,具有一定的學術研究能力
6. 有腫瘤表觀遺傳學、腫瘤免疫學、RNA藥物相關研究領域工作、研究經驗或意向者優先。有在藥企研發工作經驗者優先。有帶人經驗者優先。
7. 有較強的中英文口頭稱述、溝通和書面表達能力
8. 熟練使用office和使用科研分析軟件
9. 學習能力強,積極主動,有進取心、責任心、領導力、團隊合作精神,溝通能力強,適應能力強。
10. 公司在深圳有申請深圳高層次/孔雀人才機會,有意向者公司可協助申請

Minimum Requirements
1. PhD in molecular biology, biochemistry, cell Biology, immunology or related biology
2. A minimum of 2 years of industrial working experience or 2 years of postdoc training in industry.
3. With excellent expertise of in vivo approaches for cancer biology study: genetic modified mouse models, CDX/PDX/PDC models, profiling of biomarkers/PD markers with in vivo samples
4. Strong hands on skills in cancer biological, immunological, biochemical, and molecular techniques including molecular cloning, cell culture, proliferation/invasion/cell cycle/functional assays, use of primary tissues and cells, multi parameter flow cytometry (both intracellular and cell surface markers), quantification of mRNA (qPCR), generation of stable cell lines, quantification of protein expression, immunohistochemistry, and ELISA/western blotting.
5. Demonstrates ability to independently design, execute, and interpret experiments and results. Capable to manage and prioritize a number of different project responsibilities within the scope of the project team. Possesses an excellent record of accomplishment of independent biology research
6. Experience or well-understanding in cancer epigenetics, immune oncology or RNA drug research is a plus; Experience in pharmaceutical/biotech industries is preferred; Experience in people management is a plus.
7. Excellent written and verbal communication skills in both Chinese and English are required.
8. Self-motivated creative and organized to work independently and collaborative
9. Familiar with using of Office and scientific software
10. Welcome to apply talent-plan in Shenzhen

2021年8月15日 20:25
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